Does evolutionary theory need a rethink?

Education: the need for a rethink.

Mark Twain's observation about the long term effects of soap and education appeals to our common sense, but it is difficult to assess the true influence of these simple processes on society. The same is true in rheumatology. Most of us believe in the benefits of improving the rheumatological knowledge of doctors and patients, but it is difficult to prove that education is effective. What do pat...

Urological education: Do we need a rethink?

Toward Evolutionary Innovation Theory

Abstract: Innovations, commercialized by new or old established firms, located at the core of industrial renewal process. The innovation concept has suffered transformations, along with the evolution of the models that try to explain and understand the innovation process. The innovative process corresponds to all activities that generate technological changes and the dynamic interaction between...

Ethical Off-label Drug use: Need for a Rethink?

Off-label drug use is unavoidable, especially in children. Legal justice originates from ethical justice; therefore, ethical off-label drug use can be considered legal. We share our successful experiences with this issue in China, which may provide a reference to Indian healthcare professionals, to develop a common executable standard to be applied to evaluate the off-label drug use in clinical...

READER REACTION Bioequivalence TestiIlg-A Need to Rethink

The symmetric confidence interval method for bioequivalence testing, proposed by Westlake (1976, 1979), is founded on a premise which is highly questionable, and in his description of the method, Westlake confuses two distinct statistical issues. The purpose of this note is to clarify the apparent flaws in Westlake's method and to point out a formal similarity between testing drugs for bioequiv...